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Oradon is combination of Rabeprazole PPI (Proton pump inhibitor) and Domperidone a dopamine antagonist with antiemetic property which is widely used to heal gastro intestinal (Stomach & Gut) problem due to overmuch stomach acid. It heals stomach and intestinal ulcers and manages gastro Oesophageal reflux diseases GORD (A condition in which acid rises up in the stomach and reaches the oesophagus (gullet) with the symptoms of heart burn acid reurigination & pain on swallowing.
Rabeprazole sodium 20 mg
Domperidone 30 mg
(10mg immediate release & 20 mg sustained release)
It is a PPI that suppresses gastric acid secretion by inhibiting the gastric H+/K+ ATPase at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, Rabeprazole has been characterized as a gastric proton pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion.
It is a dopamine antagonist with anti-emetic properties Domperidone does not readily cross the blood-brain barrier. Its anti-emetic effect may be due to a combination of peripheral (gastro kinetic) effects and antagonism of dopamine receptors in the chemoreceptor trigger zone, which lies outside the blood-brain barrier in the area postrema.
- Acute duodenal ulcer
- Active gastric ulcers
- Gastric motility disorders
- Greater activity against H. Pylori
- Zollinger Ellison Syndrome